(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta.P-gp has been identified in mice, rat, bovine, monkey, rodents, and human beings and has been receiving a particular clinical relevance because this protein expression limits brain access and inte
ABSTRACT Obesity has been epidemiologically and empirically linked with more severe diseases upon influenza infection.To ameliorate severe disease, treatment with antivirals, such as the neuraminidase inhibitor oseltamivir, is suggested to begin within days of infection especially in high-risk hosts.However, this treatment can be poorly effective D
Hend Mohamed Anter,1 Irhan Ibrahim Abu Hashim,1 Walaa Awadin,2 Mahasen Mohamed Meshali1 1Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia, Egypt; 2Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Dakahlia, Egypt Purpose: Recently, Apocynin (APO) has emerged as a bioacti
Abstract Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes.NPC1 deficiency causes neurodegeneration, dementia and early death.Cerebellar Purkinje cells (PCs) are particularly hypersensitive to